Medico Phase 1 Unit
📍 Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma
Erhaltene Förderung: €2.900Identificazione di biomarcatori circolanti (cell-free DNA methylation + Integrated Stress Response transcripts) per predire la risposta agli inibitori del checkpoint immunitario nel tumore al polmone. Obiettivo: biopsia liquida non invasiva per selezionare i pazienti che davvero beneficiano di immunoterapia.
Identification of transcriptional and post-transcriptional regulatory mechanisms of ISR genes related to immunotherapy response in advanced NSCLC patients. Prognostic stratification based on ISR transcript half-life and identification of predictive biomarkers for acquired resistance.
Successful stratification of advanced NSCLC patients based on the regulation of ISR transcripts and their half-life dynamics. Identification of novel transcriptional and post-transcriptional mechanisms that correlate with immunotherapy resistance or response. Discovery of predictive biomarker signat…
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