Gefördertes Projekt
Stratifizierung der Immuntherapieantwort bei Patienten anhand zirkulierender Immunsystem‑assoziierter Transkripte und cfDNA-Methylierung
Marco Filetti • Fondazione Policlinico Universitario A. Gemelli IRCCS
Abstract
Obiettivo generale
Identification of transcriptional and post-transcriptional regulatory mechanisms of ISR genes related to immunotherapy response in advanced NSCLC patients. Prognostic stratification based on ISR transcript half-life and identification of predictive biomarkers for acquired resistance.
Risultati attesi
Successful stratification of advanced NSCLC patients based on the regulation of ISR transcripts and their half-life dynamics. Identification of novel transcriptional and post-transcriptional mechanisms that correlate with immunotherapy resistance or response. Discovery of predictive biomarker signat…
Schlüsseldaten
- Dauer: 24 Monate
- Förderung: €2.900
- Zentrum: Fondazione Policlinico Universitario A. Gemelli IRCCS