Funded project
Stratifying immunotherapy patients using circulating immune system–related transcripts and cfDNA methylation
Marco Filetti • Fondazione Policlinico Universitario A. Gemelli IRCCS
Abstract
Obiettivo generale
Identification of transcriptional and post-transcriptional regulatory mechanisms of ISR genes related to immunotherapy response in advanced NSCLC patients. Prognostic stratification based on ISR transcript half-life and identification of predictive biomarkers for acquired resistance.
Risultati attesi
Successful stratification of advanced NSCLC patients based on the regulation of ISR transcripts and their half-life dynamics. Identification of novel transcriptional and post-transcriptional mechanisms that correlate with immunotherapy resistance or response. Discovery of predictive biomarker signat…
Key data
- Duration: 24 months
- Funding: €2.900
- Centre: Fondazione Policlinico Universitario A. Gemelli IRCCS