DONATE →
2025 call Biomarkers

Dr. Giovanna Polcaro

Researcher at UNISA, Baronissi

📍 Università degli Studi di Salerno — Dipartimento di Medicina, Chirurgia ed Odontoiatria

Grant received: €3.000
Immuno-SAFE

Saliva-based test to predict immune-related adverse events (irAEs) in NSCLC

Developing a non-invasive test based on salivary biomarkers (genetic, microbiome, immunological) to predict which lung cancer patients will develop immune-related adverse events (irAEs) before therapy begins. A precision-medicine approach combined with accessible laboratory medicine.

Scientific abstract

Immuno-SAFE: a first-in-class saliva-based genetic test for early prediction of immune-related adverse events in non–small cell lung cancer immunotherapy

Overall objective

To advance precision oncology by implementing Immuno-SAFE, a rapid and non-invasive system predicting severe irAEs in NSCLC patients eligible for anti-PD-1/PD-L1 immunotherapy. The project aims to improve treatment personalisation, enhance patient safety, reduce avoidable hospitalisations, and support the regional and national transition toward more efficient, sustainable immunotherapy management.

Expected results

Early and accurate identification of NSCLC patients at high risk of severe irAEs, enabling more personalised and safer immunotherapy pathways. Reduction of treatment interruptions, emergency admissions, and irAE-related healthcare costs. Strengthened precision oncology services across regional centres, improving clinical workflow efficiency, the sustainability of immunotherapy programmes, and overall patient outcomes.

Project key data

Formal title
Immuno-SAFE: a first-in-class saliva-based genetic test for early prediction of immune-related adverse events in non–small cell lung cancer immunotherapy
Expected duration
24 months
Funding
€3.000
Research centre
Dipartimento di Medicina, Chirurgia ed Odontoiatria; Baronissi (SA), 84081; Università degli studi di Salerno

Details

Call edition
Strongers for Research 2025
Awarded on
31 March 2026
Source
2025 call — award notified 31/03/2026

Fund the next researcher

Every €3,000 raised = one more grant in the next call. You run, you donate, they do research.

Donate now See the open call
← All funded researchers