Physician-researcher in Onco-Pulmonology
📍 Azienda Ospedaliero-Universitaria Pisana — Pulmonary Unit
Grant received: €3.000A real-world analysis of the incidence of checkpoint inhibitor–induced pneumonitis (CIP) in lung cancer patients treated with immunotherapy. A 10-year retrospective cohort at AOU Pisana (~1,000 patients). Trials report a CIP rate of 2.7-4.1%, but real-world data show 10-19%, with 20% steroid-refractory and high mortality.
Thanks to the Strongers grant, Guido Marchi presented the preliminary IMPEREAL project at the international Annual Meeting of the Japanese Respiratory Society and took part in the American Thoracic Society Congress, engaging with emerging issues in immunotherapy-related lung toxicity. The project is currently under development: collection and systematisation of clinical, radiological and therapeutic data from the real-world cohort, structuring of the preliminary statistical analysis, and a literature review on immunotherapy-related pneumonitis.
«The grant concretely made it possible to present the project in international scientific settings.»
— Guido Marchi
To generate real-world epidemiological evidence on the incidence, clinical-radiological phenotypes, and risk factors of checkpoint inhibitor–related pneumonitis (CIP) in lung cancer patients, bridging the gap between trial data and clinical practice. The study will provide insights into CIP incidence and multidimensional characteristics, potentially informing future research and the refinement of diagnostic and management strategies.
Comprehensive characterisation of real-world CIP epidemiology in a 10-year lung cancer cohort, including accurate incidence rates by ICI class, identified risk factors, multidimensional clinical phenotypes, and outcome patterns. Dissemination of findings through peer-reviewed publications and international conference presentations. Development of evidence-based recommendations supporting the refinement of CIP diagnostic criteria and management strategies applicable across different healthcare systems.
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