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2025 call Tossicità immuno-correlate

Dr. Guido Marchi

Medico ricercatore Onco-Pulmonology

📍 Azienda Ospedaliero-Universitaria Pisana — Pulmonary Unit

Grant received: €3.000
IMPEREAL

Immune Checkpoint Inhibitor–Related Pneumonitis: Real-World Incidence Analysis in Lung Cancer Patients

Analisi real-world dell'incidenza di polmonite indotta da inibitori del checkpoint immunitario (CIP) in pazienti con tumore al polmone trattati con immunoterapia. Coorte retrospettiva di 10 anni presso AOU Pisana (~1.000 pazienti). I trial registrano CIP rate 2,7-4,1%, il real-world dice 10-19%: il 20% steroid-refractory con alta mortalità.

Scientific abstract

Immune Checkpoint Inhibitor–Related Pneumonitis: a Retrospective Real-World Incidence Analysis in Lung Cancer Patients [IMPEREAL study]

Obiettivo generale

To generate real-world epidemiological evidence on the incidence, clinical-radiological phenotypes, and risk factors of checkpoint inhibitor–related pneumonitis (CIP) in lung cancer patients, bridging the gap between trial data and practice. The study will provide insights on CIP incidence and multidimensional characteristics, potentially informing future research and refinement of diagnostic and…

Risultati attesi

Comprehensive characterization of real-world CIP epidemiology in a 10-year lung cancer cohort, including accurate incidence rates by ICI class, identified risk factors, multidimensional clinical phenotypes, and outcome patterns. Dissemination of findings through peer-reviewed publications and intern…

Project key data

Formal title
Immune Checkpoint Inhibitor–Related Pneumonitis: a Retrospective Real-World Incidence Analysis in Lung Cancer Patients [IMPEREAL study]
Expected duration
24 months
Funding
€3.000
Research centre
Azienda Ospedaliero-Universitaria Pisana

Details

Call edition
Strongers for Research 2025
Awarded on
31 marzo 2026
Source
Bando 2025 — Comunicazione premio 31/03/2026

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